Found in the Sierra Nevada mountains abutting the north-western edge of the Mojave desert. As a member of the "tiger lilly" group, this plant puts on a dazzling show each July till August. Mostly found on moist hillsides, seeps and near creeks.
Another of the desert belly flowers, L. setosissima ssp. setosissima differs from its sister taxa L. s. ssp. setosissima most obviously by its lack of floral speckling. Currently, Langloisia is a described as a monotypic genus, meaning that this species is the only one currently contained within.